| Name | Opponent | Date |
|---|---|---|
| Perfect Game | ||
| Cy Young | Philadelphia | 5/5/1904 |
| No-Hitter | ||
| Jon Lester | Kansas City Royals | 5/19/2008 |
| Clay Buchholz | Baltimore Orioles | 9/1/2007 |
| Derek Lowe | Tampa Bay Devil Rays | 4/27/2002 |
| Hideo Nomo | Baltimore Orioles | 4/4/2001 |
| Matt Young | Cleveland Indians | 4/12/1992 |
| Dave Morehead | Cleveland Indians | 9/16/1965 |
| Bill Monbouquette | Chicago White Sox | 8/1/1962 |
| Earl Wilson | Los Angeles Angels | 6/26/1962 |
| Mel Parnell | Chicago White Sox | 7/14/1956 |
| Howard Ehmke | Philadelphia A's | 9/7/1923 |
| Babe Ruth, Ernie Shore | Washington Senators | 6/23/1917 |
| Dutch Leonard | Detroit Tigers | 8/30/1916 |
| Rube Foster | New York Yankees | 6/21/1916 |
| Joe Wood | St. Louis Cardinals | 7/29/1911 |
| Cy Young | New York Yankees | 6/30/1908 |
| Bill Dinneen | Chicago White Sox | 9/27/1905 |
| Jesse Tannehill | Chicago White Sox | 8/17/1904 |
| Hit for the Cycle | ||
| John Valentin | 6/6/1996 | |
| Scott Cooper | 4/12/1994 | |
| Mike Greenwell | 9/14/1988 | |
| Rich Gedman | 9/18/1985 | |
| Dwight Evans | 6/28/1984 | |
| Fred Lynn | 5/13/1980 | |
| Bob Watson | 9/15/1979 | |
| Carl Yastrzemski | 5/14/1965 | |
| Lou Clinton | 7/13/1962 | |
| Bobby Doerr | 5/13/1947 | |
| Ted Williams | 7/21/1946 | |
| Bob Johnson | 7/6/1944 | |
| Bobby Doerr | 5/17/1944 | |
| Leon Culberson | 7/3/1943 | |
| Joe Cronin | 8/2/1940 | |
| Moose Solters | 8/19/1934 | |
| Roy Carlyle | 7/21/1925 | |
| Tris Speaker | 6/9/1912 | |
| Patsy Dougherty | 7/29/1903 | |
