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Harrell hasn't pitched beyond the fifth in any of his last three starts, going 0-2 with an 8.79 ERA in that span. Harrell made news after his most recent start, saying he wasn't a fan of the Astros' frequent defensive shifts.
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The Pirates gave Locke a job based on his Minor League resume, but even they may have been surprised by his consistency and borderline-dominant command. He has allowed 18 hits in his last 30 innings over five starts.
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Garza makes his first start of the season -- and first in exactly 10 months -- Tuesday against the Pirates. The right-hander missed the second half of 2012 with right shoulder issues before opening this season on the DL with a left lat strain.
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Samardzija returns to PNC Park, where he won on Opening Day. In that game, he whiffed nine and held the Bucs to two hits in eight shutout innings. He didn't get another win, though, until his last start vs. the Rockies. His splitter is his key pitch.